Vitamin D and bone health: interpreting observational studies
نویسندگان
چکیده
منابع مشابه
Vitamin D and bone health
Throughout the life-cycle, the skeleton requires optimum development and maintenance of its integrity to prevent fracture. Bones break because the loads placed upon them exceed the ability of the bone to absorb the energy involved. It is now estimated that 1:3 women and 1:12 men over the age of 55 years will suffer from osteoporosis in their lifetime and in the UK, at a cost in excess of £1.7 b...
متن کاملVitamin D and Bone Health
The vitamin D3 molecule, or cholecalciferol, is now considered a hormone that acts on multiple homeostatic fronts, either skeletal or extra-skeletal. After 100 years since from its identification as a protective and curative factor of rickets, during the last decade the interest in vitamin D among scientists and general public increased substantially and the use of vitamin D supplements has inc...
متن کاملVitamin D and Bone Health
Winter 2006 • Vol. 1 – No. 3 ABSTRACT Despite the availability of a wide variety of foods and supplements, and a growing interest in nutrition, the incidence of Vitamin D defi ciency is on the rise in the United States. Because vitamin D enhances the availability of calcium for bone mineralization, disorders marked by a loss of bone strength are likewise becoming more common. The causes of this...
متن کاملVitamin D and Bone Health; Potential Mechanisms
Osteoporosis is associated with increased morbidity, mortality and significant economic and health costs. Vitamin D is a secosteriod hormone essential for calcium absorption and bone mineralization which is positively associated with bone mineral density [BMD]. It is well-established that prolonged and severe vitamin D deficiency leads to rickets in children and osteomalacia in adults. Sub-opti...
متن کاملVitamin D Binding Protein and Bone Health
Vitamin D binding protein (DBP) is the major carrier protein of 25-hydroxyvitamin D (25(OH) D) in the circulation, where it may serve roles in maintaining stable levels during times of decreased 25(OH) availability and in regulating delivery of 25(OH) D to target tissues. Several genetic polymorphisms of DBP have been described that lead to phenotypic changes in the protein that may affect affi...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 2017
ISSN: 0954-6820
DOI: 10.1111/joim.12639